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One of the most important questions in microbiome research today is: how--by what mechanism--do microbes impact host health? We recently developed a computational approach that leverages known interspecies protein-protein interactions to answer this question. Our approach implicates thousands of bacterial proteins in specific pathophisological mechanisms related to type 2 diabetes (T2D), colorectal cancer (CRC), obesity and inflammatory bowel disease (IBD), among others. We are pursuing multiple lines of investigation to determine how to translate these findings into novel therapeutics and diagnostics for microbiome-related diseases.

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